You need to ensure that ControlMyJoystick sends it’s commands (keystrokes, mouse movements and clicks) to the game and not some other window such as your web browser. You can use Profile App Targets to accomplish this.
Note: Once you have set the target app and enabled targets, all ControlMyJoystick commands will be sent to the target window. For easy testing, open Notepad and set it as the target.
Setting an App Target
Right-click on the active profile to bring up the popup menu, or double-click on the target name at the bottom of the screen. Select the target program from the list.
Enabling App Targeting
Slide the profile targeting switch to the on position.